The CD274 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to B7h, B7H1, CD274, PDCD1L1, and PDL1. This antibody recognizes Human antigen. The CD274 Polyclonal Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner